CTLA-4 gene polymorphisms and risk of idiopathic recurrent pregnancy loss in a Tunisian population
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چکیده
منابع مشابه
P-212: Association between Polymorphisms of CTLA-4 Gene and Unexplained Recurrent Spontaneous Abortion in An Iranian Population
Background: Unexplained recurrent spontaneous abortion (URSA) has been suggested being associated with the failure of fetal-maternal immunologic tolerance in which the regulatory T lymphocytes (Tregs) play a crucial role. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is expressed transiently on activated T cells and constitutively on Tregs. CTLA-4 interacts with the B7 cell surface molec...
متن کاملCTLA-4 gene polymorphisms in Tunisian patients with Graves' disease.
Graves' disease (GD) is an organ-specific autoimmune disorder of multifactorial etiology with a polygenic mode of inheritance. A recent report has demonstrated that there is a linkage and an association between the genetic markers of the CTLA-4 gene on chromosome 2q33 and GD. In order to confirm this association in a Tunisian population, three polymorphisms of the CTLA-4 gene were analyzed: the...
متن کاملAssociation between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis
Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. We aimed to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL risk in the Iranian population. PubMed, Web of Science, Google Scholar, an...
متن کاملP-210: Estrogen Receptor Beta Gene Polymorphisms and Recurrent Pregnancy Loss: A Case- Control Study in A Population of Iranian Women
Background: Recurrent pregnancy loss (RPL), that affects 1-5% of couples, is a multifactorial disorder as both genetic and environmental factors are involved. The aim of this study was to determine association of single nucleotide polymorphisms (SNPs) located on estrogen receptor beta (ERβ) gene with the risk of RPL in a population of Iranian women; +1082G>A (rs1256049) in exon 5, +1730G>A (rs4...
متن کاملinterleukin-6 and interleukin-10 gene polymorphisms and recurrent pregnancy loss in romanian population
background: approximately 10-14% of the clinically acknowledged pregnancies end with spontaneous abortion at caucasian population. possible immunologic causes of recurrent miscarriages have been extensively researched. the change in the cytokines balance synthesis in favor of those synthesized by th2 cells with an increase of interleukin 6 (il6) and interleukin10 (il10) secretion is considered ...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2014
ISSN: 1471-2164
DOI: 10.1186/1471-2164-15-s2-p11